Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from SND1 knockdown clones of human HCC cell line QGY-7703

ABSTRACT: Staphylococcal nuclease domain-containing protein 1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) and positively regulates development and progression of HCC. We established stable clones expressing SND1 shRNA in QGY-7703 cells and analyzed the gene expression profiles of a control clone and two SND1 knockdown clones to check what genes are regulated by SND1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE44601 | GEO | 2013/04/01

SECONDARY ACCESSION(S): PRJNA190626

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Expression data from SND1 knockdown clones of human HCC cell line QGY-7703

Project description:Staphylococcal nuclease domain-containing protein 1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) and positively regulates development and progression of HCC. We established stable clones expressing SND1 shRNA in QGY-7703 cells and analyzed the gene expression profiles of a control clone and two SND1 knockdown clones to check what genes are regulated by SND1. Steady-state proliferating cells were collected for RNA extraction and Affymetrix microarray hybridization. Three biological replicates each of a control clone and 2 SND1 knockdown clones.

2013-04-01 | E-GEOD-44601 | biostudies-arrayexpress

The methylarginine reader function of SND1 is oncogenic

Project description:Staphylococcal nuclease Tudor domain containing 1 (SND1) protein is an oncogene that “reads” methylarginine marks through its Tudor domain. Specifically, it recognizes methylation marks deposited by protein arginine methyltransferase 5 (PRMT5), which is also known to promote tumorigenesis. SND1 is a known driver of hepatocellular carcinoma, but it is unknown if the Tudor domain is needed to drive this disease. We sought to identify the biological role of the SND1 Tudor domain in normal and tumorigenic settings. To do so, we developed two genetically engineered SND1 mouse models, namely a knockout (Snd1 KO) and a Snd1 Tudor domain mutated (Snd1 KI) mouse. Transcriptome analysis of normal KO and KI liver samples reveals a role for the SND1 Tudor domain in regulating expression of major acute phase proteins (APPs) and genes involved in the unfolded protein response (UPR), which could provide mechanistic insight into SND1’s functions in a tumor setting. These processes may provide insight into how SND1 functions as an oncogene. These results support the use of PRMT5 inhibitors, and the development of small molecule inhibitors that target the SND1 Tudor domain, as novel treatments for HCC.

2024-09-07 | GSE237559 | GEO

SND1 is a novel regulator of endothelial function

Project description:Staphylococcal nuclease and tudor domain containing protein 1 (SND1), which is also known as p100 or Tudor-SN, is a recently identified protein that is highly expressed in multiple cancers including breast cancer, liver cancer, and colon cancer. Endothelial function and vascular integrity are critical modulators in cancer metastasis and progression. Although much progress has been made in studying SND1’s oncogenic role, the involvement of SND1 in endothelial function has never been explored.

2024-10-30 | GSE219194 | GEO

snd1

Project description:Danio rerio snd1, staphylococcal nuclease and tudor domain containing 1 [Source:NCBI gene;Acc:324404], is differentially expressed in 2 experiment(s);

| ENSDARG00000006766 | ExpressionAtlas

snd1

Project description:Danio rerio snd1, staphylococcal nuclease and tudor domain containing 1 [Source:NCBI gene;Acc:324404], is expressed in 1 baseline experiment(s);

| ENSDARG00000006766 | ExpressionAtlas

Snd1

Project description:Rattus norvegicus Snd1, staphylococcal nuclease and tudor domain containing 1 [Source:RGD Symbol;Acc:631340], is differentially expressed in 26 experiment(s);

| ENSRNOG00000031173 | ExpressionAtlas

Snd1

Project description:Rattus norvegicus Snd1, staphylococcal nuclease and tudor domain containing 1 [Source:RGD Symbol;Acc:631340], is expressed in 10 baseline experiment(s);

| ENSRNOG00000031173 | ExpressionAtlas

SND1

Project description:Monodelphis domestica SND1, staphylococcal nuclease and tudor domain containing 1 [Source:NCBI gene;Acc:100014541], is expressed in 2 baseline experiment(s);

| ENSMODG00000015182 | ExpressionAtlas

SND1

Project description:Sus scrofa SND1, staphylococcal nuclease and tudor domain containing 1 [Source:VGNC Symbol;Acc:VGNC:93287], is differentially expressed in 2 experiment(s);

| ENSSSCG00000016590 | ExpressionAtlas

SND1

Project description:Homo sapiens SND1, staphylococcal nuclease and tudor domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30646], is differentially expressed in 169 experiment(s);

| ENSG00000197157 | ExpressionAtlas

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data