Expression data from neurotrophin transgenic mice
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ABSTRACT: A limited number of growth factors are capable of regulating numerous developmental processes, but how they accomplish this is unclear. In the gustatory system, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) have different developmental roles but exert their effects through the same receptors (TrkB and p75). Using genome wide expression analysis, we determined that BDNF and NT4 also regulate the expression of different sets of genes downstream of receptor signaling in geniculate ganglion. These differences in gene expression likely determine their different roles. BDNF and NT4 could function differently because of temporal or spatial differences of expression or the activation of different signaling pathways.
ORGANISM(S): Mus musculus
PROVIDER: GSE44734 | GEO | 2013/02/28
SECONDARY ACCESSION(S): PRJNA191107
REPOSITORIES: GEO
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