Transcriptomics

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Expression data from cultured rat right ventricular papillary muscles


ABSTRACT: Several different mechanical signals have been proposed to control the extent and pattern of myocardial growth and remodeling, though this has largely been studied using in vitro model systems that are not representative of intact myocardium or in vivo models in which isolating the effects of individual candidate stimuli is exceedigly difficult. We used a unique tissue culture system that allows the simultaneous control of multiple mechanical inputs and other potentially confounding stimuli (e.g., hormonal). Following a 12 hour culture period under prescribed mechanics, we used microarrays to identify genes that are up- or down-regulated in response to different amounts of mean stretch and cyclic shortening.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE45250 | GEO | 2013/03/19

SECONDARY ACCESSION(S): PRJNA193317

REPOSITORIES: GEO

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