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DNA Methylation data from early human B-cell development

ABSTRACT: A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network. Nucleic Acids Res. 2012 Dec;40(22):11339-51. We examined DNA methylation and RNA expression status during early B-cell development by sorting multiple replicates of four separate stages of pre-B cells derived from normal human fetal bone marrow and applied high-dimension DNA methylation scanning and expression arrays. We identified a distinct development-dependent demethylation signature which has gene expression regulatory properties for pre-B cells, and provide a catalog reference for the epigenetic changes that occur in pre-B-cell leukemia and other B-cell-related diseases.

ORGANISM(S): Homo sapiens

PROVIDER: GSE45459 | GEO | 2013/03/26

SECONDARY ACCESSION(S): PRJNA194408

REPOSITORIES: GEO

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