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Dynamic genome-wide transcriptional response of human monocyte-derived dendritic cells to IL-6 and Il-10

ABSTRACT: Single cell timecourse experiments demonstrated that though IL-6 and IL-10 activate STAT3, they generate different temporal patterns of activation, with IL-6 generating a transient activation of STAT3, and IL-10 generating a sustained STAT3 response. We hypothesized that these different STAT3 activation dynamics would dictate the differing cellular responses to the two cytokines.

ORGANISM(S): Homo sapiens

PROVIDER: GSE45466 | GEO | 2013/03/26

SECONDARY ACCESSION(S): PRJNA194093

REPOSITORIES: GEO

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Dynamic genome-wide transcriptional response of human monocyte-derived dendritic cells to IL-6 and Il-10

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