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Gene expression of CD19+ b cells

ABSTRACT: We used DNA microarray technology to assess changes in gene expression after treatment of 11 lymphoma cell lines with epigenetic drugs. We identified genes with upregulated expression in treated cell lines and with downregulated expression in B-cell lymphoma patient samples when compared to normal B cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE46062 | GEO | 2013/04/18

SECONDARY ACCESSION(S): PRJNA197427

REPOSITORIES: GEO

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Gene expression of CD19+ b cells

Project description:We used DNA microarray technology to assess changes in gene expression after treatment of 11 lymphoma cell lines with epigenetic drugs. We identified genes with upregulated expression in treated cell lines and with downregulated expression in B-cell lymphoma patient samples when compared to normal B cells. CD19+ b cells were isolated from buffy coats from diffrent healthy donors. Gene expression of healthy controls (CD19+ b cells) was used as a normal counterpart for lymphoma samples (GSE4732, GSE10846).

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