Transcriptomics

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Bacterial discrimination by Dictyostelid amoebae reveals the complexity of ancient interspecies interactions


ABSTRACT: Transcriptional profiling of D. discoideum revealed sets of genes whose expression is enriched in amoebae interacting with different species of bacteria, including sets that appear specific to amoebae interacting with Gram(+), or with Gram(-) bacteria. In a genetic screen utilizing the growth of mutant amoebae on a variety of bacteria as a phenotypic readout, we identified amoebal genes that are only required for growth on Gram(+) bacteria, including one that encodes the cell surface protein gp130, as well as several genes that are only required for growth on Gram(-) bacteria including one that encodes a putative lysozyme, AlyL. These genes are required for parts of the transcriptional response of wild-type amoebae, and this allowed their classification into potential response pathways.

ORGANISM(S): Dictyostelium discoideum

PROVIDER: GSE46386 | GEO | 2013/05/20

SECONDARY ACCESSION(S): PRJNA198906

REPOSITORIES: GEO

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