Comparison of the translational program in oocytes from wild type and Areg KO mice
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ABSTRACT: The study tests the hypothesis that maternal mRNA translation in oocytes is sensitive to the environment in which the oocytes mature. Amphiregulin (AREG) is a critical signal for oocyte maturation but also for oocyte developmental competence. Here we have used a genome-wide approach to determine whether the oocyte translational program is affected when oocytes mature in vivo in the absence of AREG. To this aim, polysome arrays were used to define patterns of transcript recruitment to the polysomes in oocytes derived from wild type mice and mice homozygous null for the Areg gene.
ORGANISM(S): Mus musculus
PROVIDER: GSE46640 | GEO | 2013/10/02
SECONDARY ACCESSION(S): PRJNA201340
REPOSITORIES: GEO
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