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Streptococcus suis 05ZY: control vs. treated by licochalcone A

ABSTRACT: Streptococcus suis is an important emerging worldwide pig pathogen and zoonotic agent with rapid evolution of virulence and drug resistance. Licochalcone A, used in traditional Chinese medicine, exhibits antimicrobial, antioxidant and anti-inflammatory activities. Herein, a whole-genome DNA microarray was used to investigate the global transcriptional regulation of Streptococcus suis 05ZYH33 treated by subinhibitory concentration of licochalcone A. 132 genes were differentially regulated upon liochalcone A treatment, including 78 genes up-regulated and 54 genes down-regulated which included many central biological functions such as metabolism, transcription and translation. We tried to investigate the antimicrobial mechanism of licochalcone A in the aspect of bacterial cell cycle control. Our analysis indicated that licochalcone A might inhibit the growth of S. suis by controlling the replication initiation and cell division through amino acid metabolism.

ORGANISM(S): Streptococcus suis 05ZYH33

PROVIDER: GSE46666 | GEO | 2013/05/07

SECONDARY ACCESSION(S): PRJNA201434

REPOSITORIES: GEO

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Streptococcus suis 05ZY: control vs. treated by licochalcone A

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