Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data generated from post-mortem human brain tissue originating from neurologically and neuropathologically control individuals

ABSTRACT: This data set was generated by the UK Brain Expression Consortium and consists of gene expression data generated from post-mortem human brain samples, dissected from 10 brain regions and originating from a large cohort of neurologically and neuropathologically normal individuals. The UK Brain Expression Consortium has generated gene expression data on a large cohort of neurologically and neuropathologically normal individuals in order to better understand gene expression differences across the human brain. This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE46706 | GEO | 2013/06/27

SECONDARY ACCESSION(S): PRJNA202084

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene-level analysis of 1231 samples originating from 134 Caucasian individuals

Project description:This data set was generated by the UK Brain Expression Consortium and consists of gene expression data generated from post-mortem human brain samples, dissected from 10 brain regions and originating from a large cohort of neurologically and neuropathologically normal individuals. The UK Brain Expression Consortium has generated gene expression data on a large cohort of neurologically and neuropathologically normal individuals in order to better understand gene expression differences across the human brain.

2014-08-29 | GSE60862 | GEO

Exon-level analysis of 1231 samples originating from 134 Caucasian individuals

2014-08-29 | GSE60863 | GEO

Gene-level analysis of 1231 samples originating from 134 Caucasian individuals

2014-08-29 | E-GEOD-60862 | biostudies-arrayexpress

Exon-level analysis of 1231 samples originating from 134 Caucasian individuals

2014-08-29 | E-GEOD-60863 | biostudies-arrayexpress

Expression data generated from post-mortem human brain tissue originating from neurologically and neuropathologically control individuals

Project description:This is a subset of the data set generated by the UK Brain Expression Consortium. This subset has been used specifically to study the effects of age on gene expression in multiple human tissues, and all samples originate from a single brain bank, the MRC Sudden Death Brain and Tissue Bank in Edinburgh. The UK Brain Expression Consortium has generated gene expression data on a large cohort of neurologically and neuropathologically normal individuals in order to better understand gene expression differences across the human brain. 932 samples are analysed in total originating from 100 Caucasian individuals. From each individual, up to ten brain regions were sampled and analysed.

2013-06-27 | E-GEOD-46706 | biostudies-arrayexpress

Expression data generated from post-mortem human brain tissue originating from neurologically and neuropathologically control individuals

Project description:Expression data generated from post-mortem human brain tissue originating from neurologically and neuropathologically control individuals

| PRJNA202084 | ENA

mRNA-Seq Expression profiling of human post-mortem BA9 brain tissue for Huntington's Disease and neurologically normal individuals

Project description:Huntingtonâs Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD brain has been documented but is incompletely understood. Here we present a genome-wide analysis of mRNA expression in human prefrontal cortex from 20 HD and 49 neuropathologically normal controls using next generation high-throughput sequencing. Surprisingly, 19% (5,480) of the 28,087 confidently detected genes are differentially expressed (FDR<0.05) and are predominantly up-regulated. A novel hypothesis-free geneset enrichment method that dissects large gene lists into functionally and transcriptionally related groups discovers that the differentially expressed genes are enriched for immune response, neuroinflammation, and developmental genes. Markers for all major brain cell types are observed, suggesting that HD invokes a systemic response in the brain area studied. Unexpectedly, the most strongly differentially expressed genes are a homeotic gene set (represented by Hox and other homeobox genes), that are almost exclusively expressed in HD, a profile not widely implicated in HD pathogenesis. The significance of transcriptional changes of developmental processes in the HD brain is poorly understood and warrants further investigation. The role of inflammation and the significance of non-neuronal involvement in HD pathogenesis suggest anti-inflammatory therapeutics may offer important opportunities in treating HD. 20 Huntington's Disease and 49 neurologically normal control samples from post-mortem human subjects

2015-12-08 | E-GEOD-64810 | biostudies-arrayexpress

Transcription profiling of human frontal cortex from individuals ranging from 26 to 106 years of age

Project description:Transcriptional profiling of the human frontal cortex from individuals ranging from 26 to 106 years of age. The postmortem brain tissue samples used in this study were neuropathologically normal for age, and were derived from non-demented individuals.

2007-08-04 | E-GEOD-1572 | biostudies-arrayexpress

Gene regulation and DNA damage in the aging human brain

2004-07-21 | GSE1572 | GEO

ena-DATASET-UKBEC-12-03-2015-16:21:20:556-32 - samples

Project description:Brain samples for this dataset were provided by the Medical Research Council Sudden Death Brain and Tissue Bank (Edinburgh, UK). All four individuals sampled were of European descent, neurologically normal during life and confirmed to be neuropathologically normal by a consultant neuropathologist using histology performed on sections prepared from paraffin-embedded tissue blocks. Twelve regions of the central nervous system were sampled from each individual. The regions studied were: cerebellar cortex, frontal cortex, temporal cortex, occipital cortex, hippocampus, the inferior olivary nucleus (sub-dissected from the medulla), putamen, substantia nigra, thalamus, hypothalamus, intralobular white matter and cervical spinal cord.

| EGAD00001001274 | EGA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data