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Ena-DATASET-UKBEC-12-03-2015-16:21:20:556-32 - samples

ABSTRACT: Brain samples for this dataset were provided by the Medical Research Council Sudden Death Brain and Tissue Bank (Edinburgh, UK). All four individuals sampled were of European descent, neurologically normal during life and confirmed to be neuropathologically normal by a consultant neuropathologist using histology performed on sections prepared from paraffin-embedded tissue blocks. Twelve regions of the central nervous system were sampled from each individual. The regions studied were: cerebellar cortex, frontal cortex, temporal cortex, occipital cortex, hippocampus, the inferior olivary nucleus (sub-dissected from the medulla), putamen, substantia nigra, thalamus, hypothalamus, intralobular white matter and cervical spinal cord.

PROVIDER: EGAD00001001274 | EGA |

REPOSITORIES: EGA

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Recursive splicing in long vertebrate genes.

Sibley Christopher R CR Emmett Warren W Blazquez Lorea L Faro Ana A Haberman Nejc N Briese Michael M Trabzuni Daniah D Ryten Mina M Weale Michael E ME Hardy John J Modic Miha M Curk Tomaž T Wilson Stephen W SW Plagnol Vincent V Ule Jernej J

Nature 20150513 7552

It is generally believed that splicing removes introns as single units from precursor messenger RNA transcripts. However, some long Drosophila melanogaster introns contain a cryptic site, known as a recursive splice site (RS-site), that enables a multi-step process of intron removal termed recursive splicing. The extent to which recursive splicing occurs in other species and its mechanistic basis have not been examined. Here we identify highly conserved RS-sites in genes expressed in the mammali ...[more]

PMID: 25970246

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