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Genome wide maps of H3K4me3 and H3ac histone modifications in C6 rat glioma cells [Illumina]

ABSTRACT: We report maps of H3K4me3 and H3ac - activiting expression histone modifications in C6 rat glioma cells. The data was obtained using whole genome high throughput technology. The sequencing was performed on HiSeq Ilumina platform.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE46820 | GEO | 2015/05/07

SECONDARY ACCESSION(S): PRJNA203296

REPOSITORIES: GEO

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Genome wide maps of H3K4me3 and H3ac histone modifications in C6 rat glioma cells [Illumina]

Project description:We report maps of H3K4me3 and H3ac - activiting expression histone modifications in C6 rat glioma cells. The data was obtained using whole genome high throughput technology. The sequencing was performed on HiSeq Ilumina platform. Examination of H3K4me3 histone modification and H3ac histone modification in C6 rat glioma cell line

2015-05-07 | E-GEOD-46820 | biostudies-arrayexpress

Genome wide map of H3K4me3 histone modification in C6 rat glioma cells [SOLiD]

Project description:We report a map of H3K4me3 - an activiting expression histone modification in C6 rat glioma cells. The data was obtained using whole genome high throughput technology. The sequencing was performed on Solid 5500xl platform. Examination of H3K4me3 histone modification in C6 rat glioma cell line

2015-05-07 | E-GEOD-46822 | biostudies-arrayexpress

Genome wide map of H3K4me3 histone modification in C6 rat glioma cells [SOLiD]

2015-05-07 | GSE46822 | GEO

Genome wide map of Stat3 binding sites in C6 rat glioma cells [NimbleGen]

Project description:We report a map of Stat3 binding sites in C6 rat glioma cells. The data was obtained using whole genome technology using NimbleGen microarrays. Examination of Stat3 binding sites in C6 rat glioma cell line

2015-05-07 | E-GEOD-47020 | biostudies-arrayexpress

Profiling of glioma C6 and astrocytes rat cell lines before and after co-cultivation.

Project description:We have grown C6 glioma cells and rat astrocytes, as well as astrocyte cells co-cultured together with C6 glioma. We performed proteome-wide LC-MS analysis of this experimental groups. The data including LC-MS/MS raw files and exported MaxQuant report. For our co-cultivated in vitro model we used astrocytes and C6 glioma cells. Astrocytes cell lines isolated from rat brain tissue. We analyzed astrocytes in two conditions: beforeand after co-cultivation. Proteins were assessed in an untargeted label-free bottom-up proteomic experiment using IDA approach (i.e. InformationDependent Acquisition) on AB Sciex TripleTOF 6600 Q-TOF mass-spectrometer coupled with LFQ (label-free quantification) approach by MaxQuant software. Dataset covers 165 samples (11 biological rand 5 technical replicates)

2021-10-05 | PXD026776 | Pride

Self-maintenance of rat C6 glioma stem cells (GSCs) by their non-GSC progenies

Project description:Analysis of Hoechst 33342 dye-effluxing side population cells (SP cells defined as glioma stem cells, GSCs) and dye-retaining main population cells (MP cells defined as non-GSCs) that were FACS-sorted from the C6 glioma cell line stably expressing EGFP (C6-eGFP). ECM-related genes, such as Col4a1 and Col4a2, and the iron carrier gene Tf are upregulated in MP cells. Results provide the insight into molecular basis underlying the maintenance of GSCs by non-GSCs.

2016-01-01 | GSE72431 | GEO

Genome wide map of Stat3 binding sites in C6 rat glioma cells [NimbleGen]

Project description:We report a map of Stat3 binding sites in C6 rat glioma cells. The data was obtained using whole genome technology using NimbleGen microarrays.

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Self-maintenance of rat C6 glioma stem cells (GSCs) by their non-GSC progenies

2016-07-03 | E-GEOD-72431 | biostudies-arrayexpress

Microglia treatment with C6 glioma-conditioned medium or with LPS

Project description:Several independent microglia preparations performed on different days were plated onto wells of 24-well plates, and either left untreated (control), treated with the C6 glioma-conditioned medium, or treated with LPS.<br>For each culture condition, a number of RNA samples were prepared, with each sample then separately labeled and hybridized. These RNA samples were prepared from non-overlapping sets of wells from at least two microglia preparations, so they constitute biological replicates.

2012-12-14 | E-MEXP-2466 | biostudies-arrayexpress

Borna disease virus phosphoprotein expression affects glial functions in the C6 glioma cells

Project description:Borna disease virus (BDV) is a highly neurotropic negative-strand RNA virus that belongs to the Mononegavirales. Many reports demonstrated that natural infection of BDV occurs worldwide in a variety of vertebrate species, suggesting that host range of this virus includes all warm-blooded animals. BDV persistently infects the central nervous system (CNS) of many animal species and causes neurobehavioral disorders resembling autism, such as anxiety, aggression, hyperactivity, abnormal play behavior, and cognitive deficits. We previously reported the generation of transgenic mice expressing BDV phosphoprotein (P) selectively in astrocytes. This transgenic mouse, P-Tg, showed striking neurobehavioral abnormalities resembling those in BDV-infected animals, such as enhanced intermale aggressiveness, hyperactivity and spatial reference memory deficit. To reveal the molecular mechanisms how glial cells induce these abnormalities, we performed microarray analysis using C6 rat glioma cells expressing either GFP (C6-GFP) or BDV P (C6-P). Sixty-eight genes are significantly affected in C6-P cells. The genes, whose products are localized at the extracellular region, were enriched in the differentially expressed genes in C6-P cells. Furthermore, gene ontology analysis revealed an emphasis on genes involved in morphogenesis. It is highly likely that the secretion of astrocyte factors may be widely dysregulated in the P-Tg, leading to the astrocyte hypofunction in the brain.

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