Transcriptomics

Dataset Information

0

Comparative analysis of gene expression by human Umblical Cord (UCB)-CD34+ Hematopoietic Stem Cells (HSCs) and human induced pluripotent stem (iPS) cell-derived CD34+ Hematopoietic Progenitor Cells (HPCs)


ABSTRACT: Hematopoietic stem and progenitor cells are a rare, self-renewing bone marrow resident population capable of giving rise to all circulating hematopoietic cells. They can be used therapuetically for reconstituting defective or ablated hematopoietic systems following chemotherapy, and for inducing tolerance toward allografts of the same haplotype as the HSC donor. There are several sources for HSCs, such as the adult bone marrow, or umblical cord blood, which is more replete with such HSCs. However, HSCs obtained from such sources may be immunogenic, especially if isolated from adult bone marrow. To overcome this issue, our lab has establsihed human induced pluripotent stem cell-derived HPCs with the hope of creating a nonimmunogenic, readily available and unlimited source of HSCs to use for therapy. The goal of this study was to compare the gene expression profiles of naturally found HSCs (UCB-CD34+ HSCs) and HPCs differentiated from 4 different human iPS cell lines (iPS-HPCs), so as to determine the variation between the four iPS-HPCs and whether there were any differences between these HPCs and naturally found HSCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE46888 | GEO | 2013/10/23

SECONDARY ACCESSION(S): PRJNA202927

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-10-23 | E-GEOD-46888 | biostudies-arrayexpress
2012-02-18 | E-GEOD-35923 | biostudies-arrayexpress
2012-02-18 | GSE35923 | GEO
2013-11-06 | E-GEOD-48986 | biostudies-arrayexpress
2024-05-21 | PXD018535 | Pride
2013-03-06 | E-GEOD-44923 | biostudies-arrayexpress
2018-06-21 | GSE106721 | GEO
2021-11-10 | PXD025849 | Pride
2016-09-08 | GSE81390 | GEO
2012-06-25 | GSE27126 | GEO