Genomics

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MiR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells


ABSTRACT: Administration of mesenchymal stem cells (MSCs) has the potential to ameliorate degenerative disorders and to repair damaged tissues. The homing of transplanted MSCs to injured sites is a critical property of engraftment. Our aim was to identify microRNAs involved in controlling MSC proliferation and migration. MSCs can be isolated from bone marrow and umbilical cord Wharton's jelly (BM-MSCs and WJ-MSCs, respectively), and WJ-MSCs show poorer motility yet have a better amplification rate compared to BM-MSCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE46989 | GEO | 2013/09/05

SECONDARY ACCESSION(S): PRJNA203222

REPOSITORIES: GEO

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