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∆Np63 regulates stem cell activity in mammary gland development

ABSTRACT: MaSC, luminal progenitor enriched subpopulations and total MECs as well, were isolated from both wild type and ∆Np63 KO heterozygous mouse and the transcriptome profiles were determined and compared.

ORGANISM(S): Mus musculus

PROVIDER: GSE47417 | GEO | 2014/08/19

SECONDARY ACCESSION(S): PRJNA205535

REPOSITORIES: GEO

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∆Np63 regulates stem cell activity in mammary gland development

Project description:MaSC, luminal progenitor enriched subpopulations and total MECs as well, were isolated from both wild type and ∆Np63 KO heterozygous mouse and the transcriptome profiles were determined and compared. Three populations: P4, P5 and MECs; two genotypes: WT vs ∆Np63 heterozygous.

2014-08-19 | E-GEOD-47417 | biostudies-arrayexpress

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Project description:RNA samples were prepared from freshly sorted mammary cell subpopulations (MaSC/basal-enriched, luminal progenitor, mature luminal and stromal) from five human donors. High throughput RT-PCR was used to measure the global microRNA expression profiles of each cell subpopulation. The expression profiles were compared between cell subpopulations to gain insight into the regulation of lineage-restricted genes. High throughput RT-PCR profiling of microRNA expression in four mammary cell populations from five human donors.

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