Transcriptomics

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Molecular Insight into the Association between Cartilage Regeneration and Ear Wound Healing in Genetic Mouse Models: Targeting New Genes in Regeneration


ABSTRACT: Certain mouse strains have the ability to heal both ear wounds and knee articular cartilage injuries. A positive genetic correlation between cartilage healing and protection from osteoarthritis exists, which suggests that a common core of genes may operate in healing process. Here, we analyzed knee joint tissues from healer and non-healer mice and found that four genes were common to both ear wound and knee cartilage healing. Specific sequence differences between haler and non-healer parental strains were identified as potential causal polymorphisms. We suggest a common molecular and genetic basis of tissue healing.

ORGANISM(S): Mus musculus

PROVIDER: GSE48505 | GEO | 2013/07/04

SECONDARY ACCESSION(S): PRJNA210354

REPOSITORIES: GEO

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