Tet2-mediated DNA demethylation controls T cell cytokine expression [array]

ABSTRACT: The conversion of 5-methylcytosine (5mC) into 5-Hydroxymethylcytosine (5hmC) by ten-eleven translocation (Tet) family has recently been identified as a key process for active DNA demethylation, whose effects in the immune response is currently unknown. We used microarrays to characterize the regulation of Tet2 in T cells. We found that deletion of the Tet2 gene in T cells decreased expression of effector cytokines such as IFN-γ, IL-17, and IL-10.

ORGANISM(S): Mus musculus

PROVIDER: GSE48657 | GEO | 2015/04/12

SECONDARY ACCESSION(S): PRJNA210960

REPOSITORIES: GEO