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IRE1 and XBP-1 effects on the Drosophila unfolded protein response

ABSTRACT: The unfolded protein response (UPR) allows the endoplasmic reticulum (ER) to recover from the accumulation of misfolded proteins, in part by increasing its folding capacity. IRE1 promotes this remodeling by detecting misfolded ER proteins and activating a transcription factor, XBP-1, through endonucleolytic cleavage of its mRNA. We found that IRE1 independently mediated the rapid degradation of a specific subset of mRNAs. The arrays deposited here show the effects of depletion of IRE1 and XBP-1 on UPR induction in S2 cells. We have characterized the IRE1-dependent repressive branch of this response. Keywords: stress response, RNAi, DTT

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE4867 | GEO | 2006/05/20

SECONDARY ACCESSION(S): PRJNA95757

REPOSITORIES: GEO

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