Transcriptomics

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Gene expression changes resulting from the stable loss of BAP1 in uveal melanoma cell lines


ABSTRACT: Uveal melanoma is a highly aggressive cancer with a strong propensity for metastasis, yet little is known about the biological mechanisms underlying this metastatic potential. We recently showed that most metastasizing uveal melanomas, which exhibit a class 2 gene expression profile, contain inactivating mutations in the tumor suppressor BAP1. The aim of this study was to investigate the role of BAP1 in uveal melanoma progression. To that end, uveal melanoma cells were studied following stable shRNA-mediated depletion of BAP1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE48863 | GEO | 2013/09/06

SECONDARY ACCESSION(S): PRJNA212017

REPOSITORIES: GEO

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