Med1 overexpression induces cell proliferation
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ABSTRACT: Med1 overexpression leads to induction of a wide spectrum of genes. Adenovirally-driven overexpression of Med1 in mouse liver stimulates hepatocyte DNA synthesis with enhanced expression of DNA replication, cell cycle control and liver specific genes as observed at day 3 and day 5 post injection. Med1 gene is amplified in a number of cancers so in this study we tested the hypothesis that Med1 by itself has the capacity to induce cell proliferation. Analysis of the Med1- induced gene expression showed a robust induction of a wide spectrum of genes involved in hepatocellular proliferation.
ORGANISM(S): Mus musculus
PROVIDER: GSE48950 | GEO | 2013/07/18
SECONDARY ACCESSION(S): PRJNA212386
REPOSITORIES: GEO
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