Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The Tif1Beta-Hp1 system maintains transcriptional integrity of hematopoietic stem cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE48987 | GEO | 2013/11/06

SECONDARY ACCESSION(S): PRJNA212529

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

The Tif1Beta-Hp1 system maintains transcriptional integrity of hematopoietic stem cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-11-06 | E-GEOD-48987 | biostudies-arrayexpress

The TIF1β-HP1 system maintains transcriptional integrity of hematopoietic stem cells.

Project description:TIF1β is a transcriptional corepressor that recruits repressive chromatin modifiers to target genes. Its biological function and physiological targets in somatic stem cells remain largely unknown. Here, we show that TIF1β is essential for the maintenance of hematopoietic stem cells (HSCs). Deletion of Tif1b in mice induced active cycling and apoptosis of HSCs and promoted egression of HSCs from the bone marrow, leading to rapid depletion of HSCs. Strikingly, Tif1b-deficient HSCs showed a strong trend of ectopic expression of nonhematopoietic genes. Levels of heterochromatin protein 1 (HP1α, β and γ) proteins, which form a complex with TIF1β, were significantly reduced in the absence of TIF1β and depletion of HP1 recapitulated a part of the phenotypes of Tif1b-deficient HSCs. These results demonstrate that the TIF1β-HP1 system functions as a critical repressive machinery that targets genes not normally activated in the hematopoietic compartment, thereby maintaining the transcriptional signature specific to HSCs.

| S-EPMC3923190 | biostudies-literature

The Tif1Beta-Hp1 system maintains transcriptional integrity of hematopoietic stem cells

Project description:The Tif1Beta-Hp1 system maintains transcriptional integrity of hematopoietic stem cells

| PRJNA212529 | ENA

Atr maintains chromosomal integrity during postnatal cerebellar neurogenesis