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Expression data from responders/nonresponders before/after receiving DLI for relapse of CML s/p BMT

ABSTRACT: Increasing evidence across malignancies suggests that infiltrating T cells at the site of disease are crucial to tumor control. We hypothesized that marrow-infiltrating immune populations play a critical role in response to donor lymphocyte infusion (DLI), an established and potentially curative immune therapy whose precise mechanism remains unknown. We therefore analyzed marrow-infiltrating immune populations in 29 patients (22 responders, 7 nonresponders) with relapsed chronic myelogenous leukemia who received CD4+ DLI in the pre-tyrosine kinase inhibitor era. We used microarrays to detail the global programme of gene expression underlying T cell infiltration into bone marrow of responders and nonresponders to DLI.

ORGANISM(S): Homo sapiens

PROVIDER: GSE49067 | GEO | 2013/09/30

SECONDARY ACCESSION(S): PRJNA212860

REPOSITORIES: GEO

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Expression data from responders/nonresponders before/after receiving DLI for relapse of CML s/p BMT

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