Genomics

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Genome-wide map of GATA6 DNA binding in human CRC cells


ABSTRACT: We describe the genome-wide DNA-binding of GATA6 in a human CRC cell line (LS174T). GATA6 is found to bind the promoter of genes involved in the maintenance of intestinal stem cells, including genes of the Wnt and TGFbeta/BMP pathways. With this we describe a novel GATA6-dependent mechanism of stem cell maintenance in colorectal tumors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE49320 | GEO | 2014/05/20

SECONDARY ACCESSION(S): PRJNA213625

REPOSITORIES: GEO

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