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Genome-wide map of GATA6 DNA binding in human CRC cells

ABSTRACT: We describe the genome-wide DNA-binding of GATA6 in a human CRC cell line (LS174T). GATA6 is found to bind the promoter of genes involved in the maintenance of intestinal stem cells, including genes of the Wnt and TGFbeta/BMP pathways. With this we describe a novel GATA6-dependent mechanism of stem cell maintenance in colorectal tumors. Examination of GATA6 binding and H3K4me1, H3K4me3 and H3K27ac levels in a human CRC cell line by Chromatin immunoprecipitation followed by deep sequencing.

ORGANISM(S): Homo sapiens

SUBMITTER: Camille Stephan-Otto Attolini

PROVIDER: E-GEOD-49320 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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