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RMST associates with SOX2 to regulate neurogenesis [ChIP-Seq]

ABSTRACT: We report that knockdown of the lncRNA RMST changes the chromatin binding profile of the transcription factor SOX2.

ORGANISM(S): Homo sapiens

PROVIDER: GSE49404 | GEO | 2013/08/01

SECONDARY ACCESSION(S): PRJNA213908

REPOSITORIES: GEO

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RMST associates with SOX2 to regulate neurogenesis [ChIP-Seq]

Project description:We report that knockdown of the lncRNA RMST changes the chromatin binding profile of the transcription factor SOX2. Examination of SOX2 chromatin binding profile under normal and RMST-depleted conditions in differentiating neural stem cells.

2013-08-01 | E-GEOD-49404 | biostudies-arrayexpress

RMST associates with SOX2 to regulate neurogenesis [Illumina expression data]

Project description:We report that knockdown of the lncRNA RMST changes the gene expression profile of neural stem cells. RMST and SOX2 regulates a common subset of downstream targets. Examination of genome wide transcriptomic changes upon knockdown of the lncRNA RMST.

2013-08-01 | E-GEOD-49403 | biostudies-arrayexpress

RMST associates with SOX2 to regulate neurogenesis [Illumina expression data]

Project description:We report that knockdown of the lncRNA RMST changes the gene expression profile of neural stem cells. RMST and SOX2 regulates a common subset of downstream targets.

2013-08-01 | GSE49403 | GEO

RMST associates with SOX2 to regulate neurogenesis

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-08-01 | E-GEOD-49405 | biostudies-arrayexpress

RMST associates with SOX2 to regulate neurogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-08-01 | GSE49405 | GEO

Identification the Expression of Sox2 in Colorectal Cancer Tissues

Project description:Sox2 has been studied in several types of human solid tumors. The investigators found that Sox2 had higher expression level in colorectal cancer and metastatic tissues than normal tissues. So the investigators assumed that whether Sox2 plays an important role in the progression and migration of colon cancer.

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Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Project description:The pluripotency transcription factor SOX2 is essential for the maintenance of glioblastoma stem cells (GSC), which drive tumor growth and treatment resistance.To understand how SOX2 is regulated in GSCs, we utilized a proteomic approach and identified the E3 ubiquitin ligase TRIM26 as a direct SOX2-interacting protein. Unexpectedly, we found TRIM26 depletion decreased SOX2 protein levels and increased SOX2 polyubiquitination in patient-derived GSCs, suggesting TRIM26 promotes SOX2 protein stability. Accordingly, TRIM26 knockdown reduced SOX2 transcriptional activity, self-renewal capacity, and in vivo tumorigenicity in multiple GSC lines. Mechanistically, we found TRIM26, via its C-terminal PRYSPRY domain, but independent of its RING domain, stabilizes SOX2 protein by directly inhibiting the interaction of SOX2 with WWP2, which we identify as a bona fide SOX2 E3 ligase in GSCs. Our work identifies E3 ligase competition as a critical mechanism of SOX2 regulation, with functional consequences for GSC identity and maintenance.

2021-11-04 | PXD028933 | Pride

Genes regulated by Sox2 in glioma cancer cell line

Project description:Knockdown of Sox2 in LN229 gliomal cancer cells decrease their growth rates in vitro. We used microarrays to detail the global programme of gene expression in Sox2 Knockdown LN229 cells compared with mock knockdown LN229 cells Sox2 knockdown LN229 cells and and mock knockdown LN229 cells were cultured in DMEM cell culture media for RNA extraction and hybridization on Applied Biosystems Human Genome Survey Microarrays . We sought to obtain the genes regulated by Sox2 in glioma cell line.

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Genes regulated by Sox2 in colorectal cancer cell line

Project description:Knockdown of Sox2 in SW620 colorectal cancer cells decrease their growth rates in vitro and in vivo in xenograft models. We used microarrays to detail the global programme of gene expression in Sox2 Knockdown sw620 cells compared with mock knockdown sw620 cells Sox2 knockdown sw620 cells and and mock knockdown sw620 cells were cultured in RPMI 1640 cell culture media for RNA extraction and hybridization on Affymetrix microarrays. We sought to obtain the genes regulated by Sox2 in colorectal cell lines and end (T4) of gastrulation.

2011-03-01 | E-GEOD-20689 | biostudies-arrayexpress

Analysis of transcriptome changes following SOX2 knockdown in three different Ewing sarcoma cell lines

Project description:We report that knockdown of SOX2 in Ewing sarcoma cell lines promotes changes in the expression of several genes that are involved a variety of molecular processes.

2019-08-19 | GSE124221 | GEO

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