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Human BRAF-V600E melanoma cell lines drug sensitive vs drug resistant

ABSTRACT: aCGH of human melanoma cell lines comparing parental (drug sensitve) vs isogenic drug resistant-derived subline

ORGANISM(S): Homo sapiens

PROVIDER: GSE49430 | GEO | 2014/04/21

SECONDARY ACCESSION(S): PRJNA213902

REPOSITORIES: GEO

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Human BRAF-V600E melanoma cell lines drug sensitive vs drug resistant

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Transcription profiling of doxorubicin sensitive and resistant human myeloma cell lines after treatment with doxorubicin to explore the role of the STAT1 signaling pathway in drug and radiation resistance

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Project description:To identify miRNAs involved in drug resistance of human breast cancer, a miRNA microarray was performed on 5 cases of drug resistant tissues and 5 cases of drug sensitive tissues.The expression levels of totally 2019 miRNAs in 5 pairs of matched, drug resistant and drug sensitive tissues were examined by microarray. There were 27 differentially expressed miRNAs between drug resistant and drug sensitive tissues were identified of which there were 11 significantly up-regulated while the other 16 were down-regulated in drug resistant tissues compared to drug sensitive tissues. It was found that miR-489 was one of the most downregulated miRNAs in drug resistant tissues.

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