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ChIP-chip data of Npl3-Myc and Rrm3-Flag in wild-type and npl3∆ cells

ABSTRACT: Transcription is a major obstacle for replication fork progression and a cause of genome instability. Such instability increases in mutants with a suboptimal assembly of the nascent messenger ribonucleo-protein particle (mRNP), as THO/TREX and some heterogeneous nuclear ribonucleoproteins (hnRNPs) mutants. Here we show that yeast npl3∆ cells show genome-wide replication obstacles as determined by accumulation of the Rrm3 helicase. Such obstacles preferentially occur at long and highly expressed genes, to which Npl3 is preferentially bound in wild-type cells.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE50185 | GEO | 2013/11/15

SECONDARY ACCESSION(S): PRJNA217041

REPOSITORIES: GEO

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ChIP-chip data of Npl3-Myc and Rrm3-Flag in wild-type and npl3M-bM-^HM-^F cells

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