Transcriptomics

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Regulation of the KEAP1/NRF2 oxidative stress response pathway by BRD4 in prostate and colorectal cancer


ABSTRACT: To identify genes regulated by BRD4 and to provide insight into new mechanisms de-regulated by BRD4, such as the response to oxidative stress, we integrated BRD4-binding regions with BRD4 gene expression data. For this analysis we performed BRD4 chromatin immunoprecipitation experiments and BRD4 knock down experiments followed by RNA-Seq analyses. By integration of both gene lists we identified top candidate genes regulated by BRD4.

ORGANISM(S): Homo sapiens

PROVIDER: GSE50491 | GEO | 2014/02/28

SECONDARY ACCESSION(S): PRJNA217765

REPOSITORIES: GEO

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