Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gestational food-restriction but not nicotine exposure regulates gene expression in the striatum of adolescent rats

ABSTRACT: We used microarrays to determine the effect of prenatal nicotine exposure on gene expression profiles in the striatum of adolescent rats. We found a number of immediate early genes to be differentially expressed due to food-restriction.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE50607 | GEO | 2013/09/06

SECONDARY ACCESSION(S): PRJNA218073

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gestational food-restriction but not nicotine exposure regulates gene expression in the striatum of adolescent rats

Project description:We used microarrays to determine the effect of prenatal nicotine exposure on gene expression profiles in the striatum of adolescent rats. We found a number of immediate early genes to be differentially expressed due to food-restriction. We compared control (n=8), nicotine exposed (n=7) and a group of animals matched to the food intake of nicotine exposed animals (n=10) to identify gene expression changes associated with prenatal nicotine exposure

2013-09-06 | E-GEOD-50607 | biostudies-arrayexpress

miRNA expression profiles in the dorsal striatum of a mouse model of nicotine withdrawal

Project description:Nicotine withdrawal can diversely affect brain gene expression patterns. In the brain, the dorsal striatum is a hub of nicotine dependence. Previous studies have shown that nicotine dependence leads to functional alterations in the dorsal striatum. miRNAs are small non-coding RNAs that regulates cellular functions and dysfunctions. Here, we performed small RNA sequencing from the dorsal striatum of mice at 7 days after nicotine withdrawal. Our results show that nicotine withdrawal does not notably impact miRNA expression profile in the dorsal striatum, but a few miRNAs were significantly altered in response to nicotine withdrawal. These results suggest that nicotine withdrawal has a small but significant impact on the miRNA expression profile in the mouse dorsal striatum.

2024-10-31 | GSE280738 | GEO

Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats.

Project description:Gestational exposure to environmental toxins such as nicotine may result in detectable gene expression changes in later life. To investigate the direct toxic effects of prenatal nicotine exposure on later brain development, we have used transcriptomic analysis of striatal samples to identify gene expression differences between adolescent Lister Hooded rats exposed to nicotine in utero and controls. Using an additional group of animals matched for the reduced food intake experienced in the nicotine group, we were also able to assess the impact of imposed food-restriction on gene expression profiles. We found little evidence for a role of gestational nicotine exposure on altered gene expression in the striatum of adolescent offspring at a significance level of p<0.01 and |log2 fold change >0.5|, although we cannot exclude the possibility of nicotine-induced changes in other brain regions, or at other time points. We did, however, find marked gene expression differences in response to imposed food-restriction. Food-restriction resulted in significant group differences for a number of immediate early genes (IEGs) including Fos, Fosb, Fosl2, Arc, Junb, Nr4a1 and Nr4a3. These genes are associated with stress response pathways and therefore may reflect long-term effects of nutritional deprivation on the development of the stress system.

| S-EPMC3929494 | biostudies-literature

The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [RNA-seq]

Project description:Background. Prenatal exposure to nicotine has been documented to impose numerous deleterious effects on fetal development. However, the epigenetic changes promoted by nicotine exposure on germ cell are still not well understood. Objectives. In this study, we focused on elucidating the impact of prenatal nicotine exposure on regulatory epigenetic mechanisms important for the germ cells development. Objectives. In this study, we focused on elucidating the impact of prenatal nicotine exposure on regulatory epigenetic mechanisms important for the germ cells development.

2024-04-26 | GSE253595 | GEO

The prenatal nicotine exposure leads to epigenetic alterations in nervous system signaling genes in the rat [MeDIP]

2024-04-26 | GSE253594 | GEO

The influence of adolescent nicotine exposure on ethanol intake brain gene expression

Project description:The influence of adolescent nicotine exposure on ethanol intake brain gene expression

| PRJNA474041 | ENA

Effect of prenatal exposure to nicotine on kidney structure and gene expression in rats

2012-12-25 | GSE29677 | GEO

Effect of prenatal exposure to nicotine on kidney structure and gene expression in rats

Project description:Here, we investigated whether prenatal exposure to nicotine alters kidney glomerular mass and genome-wide gene expression profiles in two genetically distant strains of rats, namely spontaneously hypertensive rats (SHR) and Brown Norway (BN) rats. Nicotine or saline were administered to BN and SHR dams via osmotic pumps throughout gestation. Kidneys from 9-week-old male offspring were studied. Equal amounts of RNA from individual animals were pooled within each of the four experimental groups SHR (nicotine: n=13; saline: n=12) and BN (nicotine: n=12; saline: n=12) and hybridized with the Rat RAE-230a GeneChip (Affymetrix).

2012-12-25 | E-GEOD-29677 | biostudies-arrayexpress

Prenatal folic acid and adolescent brain development

Project description:Prenatal folic acid and adolescent brain development

| PRJNA671333 | ENA

Prenatal folic acid and adolescent brain development

Project description:Prenatal folic acid and adolescent brain development

| PRJNA671335 | ENA