Expression data from activated NK cells [miRNA]
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ABSTRACT: Natural Killer (NK) cells present natural cytotoxicity against tumor cells, although their activity is increased after activation.NK cell activation depends on a complex intracellular signaling process mediated by activating and inhibitory receptors and the functional outcome depends on the integration of the activating and inhibitory signals received. Soluble cytokines and/or ligands on target cells bind the NK cell receptors, and hence, influence the final NK cell response: attack versus ignorance. We used microarrays to detail the global programme of gene expression underlying NK cell activation by IL-2, a MHC-I-deficient target cell (K562)+IL-2 and an EBV-target cell (R69).
ORGANISM(S): synthetic construct Homo sapiens
PROVIDER: GSE50839 | GEO | 2014/09/09
SECONDARY ACCESSION(S): PRJNA219134
REPOSITORIES: GEO
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