Transcriptomics

Dataset Information

0

Genome-wide analysis of the regulatory function mediated by the small regulatory psm-mec RNA of methicillin-resistant Staphylococcus aureus


ABSTRACT: Several methicillin resistance (SCCmec) clusters characteristic of hospital-associated methicillin-resistant Staphylococcus aureus (MRSA) strains harbor the psm-mec locus. In addition to encoding the cytolysin, phenol-soluble modulin (PSM) mec, this locus has been attributed gene regulatory functions. Here we employed genome-wide transcriptional profiling to define the regulatory function of the psm-mec locus. The immune evasion factor protein A emerged as the primary conserved and strongly regulated target of psm-mec, an effect we show is mediated by the psm-mec RNA. Furthermore, the psm-mec locus exerted regulatory effects that were more moderate in extent and possibly mediated by the PSM-mec peptide. For example, expression of PSM-mec limited expression of mecA, thereby decreasing methicillin resistance. Our study shows that the psm-mec locus has a rare dual regulatory RNA and encoded cytolysin function, both with the potential to enhance MRSA virulence. Furthermore, our findings reveal a specific mechanism underscoring the recently emerging concept that S. aureus strains balance pronounced virulence and high expression of antibiotic resistance.

ORGANISM(S): Coxiella burnetii Chlamydia trachomatis Streptococcus pyogenes Staphylococcus aureus Borreliella burgdorferi Yersinia pestis

PROVIDER: GSE51366 | GEO | 2017/08/29

SECONDARY ACCESSION(S): PRJNA222833

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2009-02-14 | E-GEOD-13702 | biostudies-arrayexpress
2010-05-14 | E-GEOD-10165 | biostudies-arrayexpress
2009-01-05 | GSE10165 | GEO
2009-02-15 | GSE13702 | GEO
2017-01-06 | GSE85265 | GEO
2011-03-29 | E-GEOD-18793 | biostudies-arrayexpress
2011-03-29 | GSE18793 | GEO
2012-10-29 | E-BUGS-128 | biostudies-arrayexpress
2010-06-01 | GSE16837 | GEO
2008-09-12 | GSE8677 | GEO