Analyses of the chromatin and transcriptional basis for lateral inhibition in isolated intestinal epithelial cells.
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ABSTRACT: We analyzed chromatin modifications, DNaseI-hypersensitive sites, and occupancy of a key secretory-lineage transcription factor, ATOH1. We found that lateral inhibition in the intestine occurs through ATOH1 exerting direct control within a broadly permissive chromatin state that is established in stem cells and is highly similar in specified progenitors of divergent potential.
ORGANISM(S): Mus musculus
PROVIDER: GSE51458 | GEO | 2014/01/06
SECONDARY ACCESSION(S): PRJNA223243
REPOSITORIES: GEO
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