Transcriptomics

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Effects of Salidroside on gene expression in ischemic brain of rats


ABSTRACT: We employed DNA microarray to identify genes differentially regulated by salidroside in ischemic brain of MCAO rats. With a cut of p < .01 and 2-fold change, we found that 121 genes were upregulated and 142 genes were down-regulated in the MCAO group, compared to the sham group. Administration of salidroside (1 h after reperfusion, daily for 6 d) enhanced 28 transcripts and suppressed 16 transcripts. The genes involved in neuroplasticity and oxygen carrier were further confirmed by qRT-PCR. Our data suggest that salidroside could regulate neuroplasticity in post-ischemic stroke, in addition to its neuroportective function.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE52001 | GEO | 2015/10/30

SECONDARY ACCESSION(S): PRJNA226085

REPOSITORIES: GEO

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