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Identification of targetted gene loci by MIXL1 in the AML cell line U937

ABSTRACT: While the role of the paired-type homeobox transcription factor MIXL1 in early ebryonic development has been previously established, very little is known about the role of MIXL1 in adult hematopoiesis. To determine what role MIXL1 plays in adult hematopoietic cells, we used an established enforced expression line for FLAG-tagged MIXL1 in U937, then isolated targetted regions of the genome by ChIP-Seq. Through this analysis, we identified new putative direct transcirptional targets for MIXL1 in AML and hematopoiesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE52781 | GEO | 2014/12/31

SECONDARY ACCESSION(S): PRJNA230262

REPOSITORIES: GEO

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