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Targeting Csnk1a1 induces selective p53-dependant killing of leukemia stem cells

ABSTRACT: We found found that casein kinase 1 alpha (Csnk1a1), a serine threonine kinase and negative regulator of beta catenin, is essential for leukemia cells in vivo.

ORGANISM(S): Mus musculus

PROVIDER: GSE52928 | GEO | 2014/02/23

SECONDARY ACCESSION(S): PRJNA230476

REPOSITORIES: GEO

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Targeting Csnk1a1 induces selective p53-dependant killing of leukemia stem cells

Project description:We found found that casein kinase 1 alpha (Csnk1a1), a serine threonine kinase and negative regulator of beta catenin, is essential for leukemia cells in vivo. We examined the effect of Csnk1a1 knowckdown by gene expression profiling in primary leukemia cells.

2014-02-23 | E-GEOD-52928 | biostudies-arrayexpress

PRMT1 and CSNK1a1 control epidermal progenitor maintenance (PRMT1/CSNK1a1 transcriptome profiling data sets)

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Casein kinase 1 and 2 phosphorylate Argonaute proteins to regulate miRNA-mediated gene silencing

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