Transcriptomics

Dataset Information

0

HGRβ: Elucidation of its Role in Transcriptional Regulation and Identification of a Ligand


ABSTRACT: The human glucocorticoid receptor (GR) is expressed as two alternately spliced Cterminal isoforms: α and β. In contrast to the canonical hGRα, hGRβ is constitutively nuclear, is not thought to bind ligand, and is believed to affect gene transcription only by acting as a dominant negative to hGRα. Microarray analysis indicated that hGRβ, expressed in the absence of hGRα, can regulate gene expression, and furthermore, occupation of hGRβ with the antagonist RU-486 diminishes that capacity. Keywords: cell type comparison

ORGANISM(S): Homo sapiens

PROVIDER: GSE5310 | GEO | 2007/03/02

SECONDARY ACCESSION(S): PRJNA96319

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2008-06-13 | E-GEOD-5310 | biostudies-arrayexpress
2012-04-30 | GSE33753 | GEO
2012-04-29 | E-GEOD-33753 | biostudies-arrayexpress
2021-02-03 | E-MTAB-9017 | biostudies-arrayexpress
2014-09-01 | E-GEOD-59262 | biostudies-arrayexpress
2019-02-15 | PXD012406 | Pride
2019-02-15 | PXD012555 | Pride
2023-03-11 | PXD028039 | Pride
2020-10-26 | PXD021339 | Pride
2023-01-11 | GSE212973 | GEO