Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: GSE85197
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Michael Saikali
LAB HEAD: Carolyn Cummins
PROVIDER: PXD012406 | Pride | 2019-02-15
REPOSITORIES: Pride
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1168ARGLU1_Veh_1.raw | Raw | |||
1169ARGLU1_Veh_2.raw | Raw | |||
1170ARGLU1_Dex1.raw | Raw | |||
1171ARGLU1_Dex2.raw | Raw | |||
1172IgG_Veh_1.raw | Raw |
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Nucleic acids research 20190401 6
Stress hormones bind and activate the glucocorticoid receptor (GR) in many tissues including the brain. We identified arginine and glutamate rich 1 (ARGLU1) in a screen for new modulators of glucocorticoid signaling in the CNS. Biochemical studies show that the glutamate rich C-terminus of ARGLU1 coactivates multiple nuclear receptors including the glucocorticoid receptor (GR) and the arginine rich N-terminus interacts with splicing factors and binds to RNA. RNA-seq of neural cells depleted of A ...[more]