Transcriptomics

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Gene expression analysis in liver collected from mice administered non-toxic, toxic, or severely toxic LNA sequences


ABSTRACT: Development of LNA gapmers, antisense oligonucleotides used for efficient inhibition of target RNA expression, is limited by non-target mediated hepatotoxicity issues. In the present study, we investigated hepatic transcription profiles of mice receiving non-toxic and toxic LNA gapmers after a single and repeat administration.

ORGANISM(S): Mus musculus

PROVIDER: GSE53230 | GEO | 2014/01/08

SECONDARY ACCESSION(S): PRJNA231176

REPOSITORIES: GEO

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