Gene expression analysis in liver collected from mice administered non-toxic, toxic, or severely toxic LNA sequences
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ABSTRACT: Development of LNA gapmers, antisense oligonucleotides used for efficient inhibition of target RNA expression, is limited by non-target mediated hepatotoxicity issues. In the present study, we investigated hepatic transcription profiles of mice receiving non-toxic and toxic LNA gapmers after a single and repeat administration.
ORGANISM(S): Mus musculus
PROVIDER: GSE53230 | GEO | 2014/01/08
SECONDARY ACCESSION(S): PRJNA231176
REPOSITORIES: GEO
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