Geriatric muscle stem cells switch reversible quiescence into senescence (Set 3; Adult vs. Young)
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ABSTRACT: Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline with aging. We report that geriatric satellite cells, compared to old and adult cells, are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and this irreversibly affects their intrinsic regenerative and self-renewal capacities.
ORGANISM(S): Mus musculus
PROVIDER: GSE53726 | GEO | 2013/12/31
SECONDARY ACCESSION(S): PRJNA232726
REPOSITORIES: GEO
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