Geriatric muscle stem cells switch reversible quiescence into senescence (Set 4; Bmi1-deficient)
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ABSTRACT: Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline in geriatric satellite cells, compared to old cells are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and this irreversibly affects their intrinsic regenerative and self-renewal capacities. In geriatric mice, resting satellite cells lose reversible quiescence by switching to an irreversible pre-senescence state, caused by derepression of p16INK4a. Young Bmi1-deficient satellite cells shares similar features.
ORGANISM(S): Mus musculus
PROVIDER: GSE53727 | GEO | 2013/12/31
SECONDARY ACCESSION(S): PRJNA232727
REPOSITORIES: GEO
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