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The effect of genotype and in utero environment on inter-individual variation in neonate DNA methylomes (methylomes)

ABSTRACT: We surveyed the genotypes and DNA methylomes of 237 neonates and found 1423 punctate regions of the methylome that were highly variable across individuals, termed variably methylated regions (VMRs), against a backdrop of homogeneity. Although methQTLs were readily detected in neonatal methylomes, genotype alone did not explain the majority of the VMRs. We found that the best explanation for 75% of VMRs was the interaction of genotype with different in utero environments, including maternal smoking, maternal depression, maternal BMI, infant birth weight, gestational age and birth order.

ORGANISM(S): Homo sapiens

PROVIDER: GSE53816 | GEO | 2014/04/02

SECONDARY ACCESSION(S): PRJNA236558

REPOSITORIES: GEO

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