Transcriptomics

Dataset Information

0

Differences among inbred mouse strains in sensitivity to TGF-ß1 induced renal fibrosis: association with TIMP-1 and EGR2 expression


ABSTRACT: Alb/TGF-ß1 (TGF-ß) transgenic mice on mixed (CBAxB6) genetic background are characterized by renal fibrosis with mild or severe phenotype. Our aim was to examine the influence of genetic background on TGF-ß induced renal fibrosis in transgenic mice, and to elucidate the molecular details of strain dependent progression of fibrosis. We generated congenic B6-TGFß transgenic mice and CBAxB6-TGFß transgenic hybrid mice. Survival, proteinuria, renal histology, renal transcriptome using cDNA microarray and protein expression were analysed.

ORGANISM(S): Mus musculus

PROVIDER: GSE54441 | GEO | 2018/08/08

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2010-04-09 | GSE18648 | GEO
2012-04-01 | GSE29660 | GEO
2019-12-06 | GSE138819 | GEO
2015-09-01 | PXD002772 | Pride
2023-10-01 | GSE242295 | GEO
2024-08-23 | GSE270768 | GEO
2024-06-03 | PXD052293 | Pride
2024-06-03 | PXD052244 | Pride
2021-02-04 | PXD023720 | Pride
2018-09-10 | GSE119662 | GEO