Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition
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ABSTRACT: Alveolar type II (ATII) epithelial cells function as stem cells, contributing to alveolar renewal, repair and cancer. Therefore, they are a highly relevant model for studying lung diseases, including acute injury, fibrosis and cancer, in which signals transduced by RAS and transforming growth factor (TGF)-ß play critical roles. To identify downstream molecular events following RAS and/or TGF-ß activation, we performed proteomic analysis using a quantitative label-free approach (LC-HDMSE) to provide in-depth proteome coverage and estimates of protein concentration in absolute amounts. Contact: pjss@soton.ac.uk
INSTRUMENT(S): MALDI Synapt MS
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung
SUBMITTER: Yilu Zhou
LAB HEAD: Yihua Wang
PROVIDER: PXD023720 | Pride | 2021-02-04
REPOSITORIES: Pride
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