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Genome-wide expression profile on hiPSCs and hiPSC-derived CD33+ myeloid cells

ABSTRACT: To gain insights into which pathways might be dysregulated in JMML, we compared the transcriptome profiles among hiPSC and sorted CD33+ myeloid cells from control and patient samples. NS/JMML-derived CD33+ myeloid cells showed dysregulation in major biological processes. Moreover, a consistent expression pattern among sets of genes related to pluripotency and myeloid regulation was observed in the control, NS and NS/JMML CD33+ myeloid cells further supporting generally successful myelopoiesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE54538 | GEO | 2014/01/31

SECONDARY ACCESSION(S): PRJNA237005

REPOSITORIES: GEO

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