Genome-wide expression profile on hiPSCs and hiPSC-derived CD33+ myeloid cells
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ABSTRACT: To gain insights into which pathways might be dysregulated in JMML, we compared the transcriptome profiles among hiPSC and sorted CD33+ myeloid cells from control and patient samples. NS/JMML-derived CD33+ myeloid cells showed dysregulation in major biological processes. Moreover, a consistent expression pattern among sets of genes related to pluripotency and myeloid regulation was observed in the control, NS and NS/JMML CD33+ myeloid cells further supporting generally successful myelopoiesis. Total RNA obtained from hiPSC and sorted CD33+ myeloid cells (at day 14 of differentiation) from control and patient samples
ORGANISM(S): Homo sapiens
SUBMITTER: Angel Roman
PROVIDER: E-GEOD-54538 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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