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MES-4, an autosome-associated HMT that participates in silencing the X chromosomes in the C. elegans germ line

ABSTRACT: Microarray-based expression profiling of dissected gonads from mes-4 mutants reveals that MES-4 is required to repress expression of a set of X-linked genes. Keywords: Mutant analysis of mes-4 in dissected C. elegans gonads

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE5454 | GEO | 2006/09/30

SECONDARY ACCESSION(S): PRJNA95957

REPOSITORIES: GEO

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MES-4, an autosome-associated HMT that participates in silencing the X chromosomes in the C. elegans germ line

Project description:Microarray-based expression profiling of dissected gonads from mes-4 mutants reveals that MES-4 is required to repress expression of a set of X-linked genes. We isolated dissected gonads from mes-4(bn85) mutant adults and compared to dissected gonads from wild type (N2 animals. RNA was linearly amplified prior to labeling for all genotypes. Comparison was done in quadruplicate on independently grown and isolated animals.

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MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line.

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