Dataset Information
MES-4, an autosome-associated HMT that participates in silencing the X chromosomes in the C. elegans germ line
Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Valerie Reinke
PROVIDER: E-GEOD-5454 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line.
Development (Cambridge, England) 20061001 19
Germ cell development in C. elegans requires that the X chromosomes be globally silenced during mitosis and early meiosis. We previously found that the nuclear proteins MES-2, MES-3, MES-4 and MES-6 regulate the different chromatin states of autosomes versus X chromosomes and are required for germline viability. Strikingly, the SET-domain protein MES-4 is concentrated on autosomes and excluded from the X chromosomes. Here, we show that MES-4 has histone H3 methyltransferase (HMT) activity in vit ...[more]
