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Detection of aberrant DNA methylation in undifferentiated and differentiated mouse ES cells compared to normal tissues

ABSTRACT: Embryonic stem cells can be differentiated in vitro to produce a variety of somatic cell types. We have employed the mDIP method combined with hybridization to a CpG islend microarray . We show that this differentiation is accompanied by an intrinsic process of extensive aberrant CpG island de novo methylation that includes developmental and cancer target genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE54664 | GEO | 2014/02/05

SECONDARY ACCESSION(S): PRJNA237315

REPOSITORIES: GEO

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Detection of aberrant DNA methylation in undifferentiated and differentiated mouse ES cells compared to normal tissues

Project description:Embryonic stem cells can be differentiated in vitro to produce a variety of somatic cell types. We have employed the mDIP method combined with hybridization to a CpG islend microarray . We show that this differentiation is accompanied by an intrinsic process of extensive aberrant CpG island de novo methylation that includes developmental and cancer target genes.

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