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Transcriptome analysis of Th9 CD4+ T cells differentiated with or without Il-1beta

ABSTRACT: We report that the Th9 differenciation program is boosted in presence of Il-1beta

ORGANISM(S): Mus musculus

PROVIDER: GSE54697 | GEO | 2014/05/23

SECONDARY ACCESSION(S): PRJNA237440

REPOSITORIES: GEO

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Transcriptome analysis of Th9 CD4+ T cells differentiated with or without Il-1beta

Project description:We report that the Th9 differenciation program is boosted in presence of Il-1beta Examination of the expression profile of Th9 CD4+ T cells after 1 hour and 3 days of differentiation and after in vivo injection

2014-05-23 | E-GEOD-54697 | biostudies-arrayexpress

Transcriptome analysis of CD4+ T cells differentiated from wild-type and CD4cre IRF8flox mice

Project description:We report that the Th9 differenciation program is alterated in absence of IRF8 protein

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Comparison of gene expression in the intestinal metaplasia in Cdx2/IL-1beta mice vs IL-1beta alone

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IL-1beta activates IL-17 via calcium

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Defining a Th9 transcriptome

Project description:Microarray analyses were performed to compare gene expression in cultured mouse Th9, Th2 and Treg cells and resting versus activated Th9 cells. Three replicates were analyzed for each culture condition; Th9 unstim, Th2 unstim, Treg unstim, Th9 stim

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Tumor rejection in Cblb-/- mice depends on IL-9 and Th9 cells

Project description:Casitas B lymphoma-b (Cbl-b) is a central negative regulator of cytotoxic T and NK cells, explaining its intracellular checkpoint function in cancer. Increasing evidence highlights the importance of CD4+ T helper cell populations (e.g., IL-9 producing T cells: Th9 cells) for anti-cancer immunity. We here provide experimental evidence that Cbl-b acts as rheostat favoring regulatory T cells (Treg) at the expense of Th9 cell differentiation. Adoptively transferred tumor-model antigen specific Cblb-/- Th9 cells exert superior anti-tumor activity leading to improved melanoma control in vivo. Accordingly, blocking IL-9 in melanoma cell-exposed Cblb-/- mice reverses their tumor rejection phenotype. Single cell RNA sequencing of in vitro differentiated Th9 cells from naïve T cells isolated from WT and Cblb-/- animals revealed the transcriptomic basis for increased Th9 cells differentiation. In summary, we here first establish IL-9 and Th9 cells as key anti-tumor executers in Cblb-/- animals. This knowledge may be helpful for future improvement of adoptive T cell therapies in cancer.

2022-04-30 | GSE173395 | GEO

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