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Early gene expression in salivary gland after isoproterenol treatment

ABSTRACT: Isoproterenol, a β-adrenergic agonist, has been shown to induce salivary gland hyperplasia. To gain a better understanding of the underlying molecular changes altered by isoproterenol, microarray-based gene expression analysis was conducted on rat parotid glands at 10, 30, and 60 minutes after isoproterenol injection. After isoproterenol treatment, the number of differentially expressed genes was increased in a time-dependent manner. The regulation of up- and down-expression of genes related to cell proliferation/survival provides a better understanding of the mechanism of isoproterenol-induced parotid gland enlargement.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE54965 | GEO | 2015/03/01

SECONDARY ACCESSION(S): PRJNA238174

REPOSITORIES: GEO

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Early gene expression in salivary gland after isoproterenol treatment

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